Minoxidil topique 2 % + spironolactone orale 100 mg face à Minoxidil topique 2 % + finastéride oral 5 mg
1 essai les comparent directement, sur les mêmes patients. Voir Minoxidil topique 2 % + spironolactone orale 100 mg · Voir Minoxidil topique 2 % + finastéride oral 5 mg
Chez 60 femmes adultes atteintes d'alopécie androgénétique, un seul essai de fiabilité limitée (Sadeghzadeh Bazargan 2024) donne l'avantage au minoxidil topique 2 % associé à la spironolactone orale 100 mg plutôt qu'au finastéride oral 5 mg. À 17 semaines, 70 % des patientes (21 sur 30) sont améliorées sur photos jugées à l'aveugle contre 33,3 % (10 sur 30), et 8 sur 30 sont nettement améliorées contre aucune, des écarts significatifs. Les patientes sans aucun effet sont 6,7 % contre 16,7 %. Un résultat à confirmer.
Sadeghzadeh 2024
Essai randomisé, risque de biais élevé. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: a blinded randomized clinical trial
| Critère | Minoxidil topique 2 % + spironolactone orale 100 mg | Minoxidil topique 2 % + finastéride oral 5 mg | Écart |
|---|---|---|---|
| Amélioration marquée | 8 sur 30Voir la citationdrugs used were ineffective in 2 (6.7%) cases in the minoxidil- spironolactone group and in 5 (16.7%) cases in the minoxidil- finasteride group. In addition, 13 (43.3%) and 16 (53%) cases in the minoxidil- spironolactone and minoxidil- finasteride groups, respec- tively, responded well to the treatment. The effect of treatment was excellent in 8 (56.7%) and 0 (0%) of the mentioned groups, respec- tively, and the mentioned difference was statistically significant (p: 0.01). The response to the treatment in the FPHL was not statisti- Citation complémentaire (methode) treatment was 4 months, and follow- up examinations were per- formed 2 and 4 months after the start of treatment. The efficacy of the treatment was evaluated by the following criteria: determina- tion of the degree of hair loss using the Ludwig grade for FPHL and the Norwood– Hamilton grade for MPHL, determination of physician satisfaction by clinical images using the physician global assessment score (no change, little, somewhat, good, and excellent), and deter- mination of patient satisfaction by clinical images according to the density and thickness of the hair shafts and the extent of hair loss (worsening, no change, and improvement). Sadeghzadeh Bazargan A, Tavana Z, Dehghani A et al.. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: a blinded randomized clinical trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15979. Citation sous licence CC-BY. | 0 % (0 sur 30)Voir la citationdrugs used were ineffective in 2 (6.7%) cases in the minoxidil- spironolactone group and in 5 (16.7%) cases in the minoxidil- finasteride group. In addition, 13 (43.3%) and 16 (53%) cases in the minoxidil- spironolactone and minoxidil- finasteride groups, respec- tively, responded well to the treatment. The effect of treatment was excellent in 8 (56.7%) and 0 (0%) of the mentioned groups, respec- tively, and the mentioned difference was statistically significant (p: 0.01). The response to the treatment in the FPHL was not statisti- Citation complémentaire (methode) treatment was 4 months, and follow- up examinations were per- formed 2 and 4 months after the start of treatment. The efficacy of the treatment was evaluated by the following criteria: determina- tion of the degree of hair loss using the Ludwig grade for FPHL and the Norwood– Hamilton grade for MPHL, determination of physician satisfaction by clinical images using the physician global assessment score (no change, little, somewhat, good, and excellent), and deter- mination of patient satisfaction by clinical images according to the density and thickness of the hair shafts and the extent of hair loss (worsening, no change, and improvement). Sadeghzadeh Bazargan A, Tavana Z, Dehghani A et al.. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: a blinded randomized clinical trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15979. Citation sous licence CC-BY. | Probablement réel |
| Patients améliorés (panel photo en aveugle) | 70 % (21 sur 30)Voir la citation(70.0%) and 10 (33.3%) cases, respectively, p: 0.01), Figures 1,2. Citation complémentaire (methode) treatment was 4 months, and follow- up examinations were per- formed 2 and 4 months after the start of treatment. The efficacy of the treatment was evaluated by the following criteria: determina- tion of the degree of hair loss using the Ludwig grade for FPHL and the Norwood– Hamilton grade for MPHL, determination of physician satisfaction by clinical images using the physician global assessment score (no change, little, somewhat, good, and excellent), and deter- mination of patient satisfaction by clinical images according to the density and thickness of the hair shafts and the extent of hair loss (worsening, no change, and improvement). Citation complémentaire (valeur) spironolactone group than in the minoxidil- finasteride group (21 Sadeghzadeh Bazargan A, Tavana Z, Dehghani A et al.. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: a blinded randomized clinical trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15979. Citation sous licence CC-BY. | 33,3 % (10 sur 30)Voir la citation(70.0%) and 10 (33.3%) cases, respectively, p: 0.01), Figures 1,2. Citation complémentaire (methode) treatment was 4 months, and follow- up examinations were per- formed 2 and 4 months after the start of treatment. The efficacy of the treatment was evaluated by the following criteria: determina- tion of the degree of hair loss using the Ludwig grade for FPHL and the Norwood– Hamilton grade for MPHL, determination of physician satisfaction by clinical images using the physician global assessment score (no change, little, somewhat, good, and excellent), and deter- mination of patient satisfaction by clinical images according to the density and thickness of the hair shafts and the extent of hair loss (worsening, no change, and improvement). Citation complémentaire (valeur) spironolactone group than in the minoxidil- finasteride group (21 Sadeghzadeh Bazargan A, Tavana Z, Dehghani A et al.. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: a blinded randomized clinical trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15979. Citation sous licence CC-BY. | Probablement réel |
| Patients sans réponse au traitement | 6,7 % (2 sur 30)Voir la citationdrugs used were ineffective in 2 (6.7%) cases in the minoxidil- spironolactone group and in 5 (16.7%) cases in the minoxidil- finasteride group. In addition, 13 (43.3%) and 16 (53%) cases in the minoxidil- spironolactone and minoxidil- finasteride groups, respec- tively, responded well to the treatment. The effect of treatment was excellent in 8 (56.7%) and 0 (0%) of the mentioned groups, respec- tively, and the mentioned difference was statistically significant (p: 0.01). The response to the treatment in the FPHL was not statisti- Citation complémentaire (methode) treatment was 4 months, and follow- up examinations were per- formed 2 and 4 months after the start of treatment. The efficacy of the treatment was evaluated by the following criteria: determina- tion of the degree of hair loss using the Ludwig grade for FPHL and the Norwood– Hamilton grade for MPHL, determination of physician satisfaction by clinical images using the physician global assessment score (no change, little, somewhat, good, and excellent), and deter- mination of patient satisfaction by clinical images according to the density and thickness of the hair shafts and the extent of hair loss (worsening, no change, and improvement). Sadeghzadeh Bazargan A, Tavana Z, Dehghani A et al.. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: a blinded randomized clinical trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15979. Citation sous licence CC-BY. | 16,7 % (5 sur 30)Voir la citationdrugs used were ineffective in 2 (6.7%) cases in the minoxidil- spironolactone group and in 5 (16.7%) cases in the minoxidil- finasteride group. In addition, 13 (43.3%) and 16 (53%) cases in the minoxidil- spironolactone and minoxidil- finasteride groups, respec- tively, responded well to the treatment. The effect of treatment was excellent in 8 (56.7%) and 0 (0%) of the mentioned groups, respec- tively, and the mentioned difference was statistically significant (p: 0.01). The response to the treatment in the FPHL was not statisti- Citation complémentaire (methode) treatment was 4 months, and follow- up examinations were per- formed 2 and 4 months after the start of treatment. The efficacy of the treatment was evaluated by the following criteria: determina- tion of the degree of hair loss using the Ludwig grade for FPHL and the Norwood– Hamilton grade for MPHL, determination of physician satisfaction by clinical images using the physician global assessment score (no change, little, somewhat, good, and excellent), and deter- mination of patient satisfaction by clinical images according to the density and thickness of the hair shafts and the extent of hair loss (worsening, no change, and improvement). Sadeghzadeh Bazargan A, Tavana Z, Dehghani A et al.. The efficacy of the combination of topical minoxidil and oral spironolactone compared with the combination of topical minoxidil and oral finasteride in women with androgenic alopecia, female and male hair loss patterns: a blinded randomized clinical trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15979. Citation sous licence CC-BY. | Probablement réel |