Minoxidil topique 2 % face à Microneedling hebdomadaire + minoxidil topique 2 %
1 essai les comparent directement, sur les mêmes patients. Voir Minoxidil topique 2 % · Voir Microneedling hebdomadaire + minoxidil topique 2 %
Chez 40 femmes chinoises atteintes d'alopécie à motif féminin, ajouter un microneedling hebdomadaire au minoxidil topique 2 % fait nettement mieux que le minoxidil seul en 24 semaines. Le nombre de cheveux par cm² passe de 84,5 à 121,9 avec l'association contre 83,8 à 96,35, et 85 % des patientes (17 sur 20) sont jugées améliorées par leur médecin contre 45 % (9 sur 20) (Zhang 2022). En revanche, une pilosité accrue ailleurs sur le corps touche 10 patientes sur 20 contre 3 sur 20, sans que l'écart soit testé. L'essai est unique et de fiabilité modérée.
Zhang 2022
Essai randomisé, risque de biais modéré. Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population
| Critère | Minoxidil topique 2 % | Microneedling hebdomadaire + minoxidil topique 2 % | Écart |
|---|---|---|---|
| Densité capillaire totale | 83,8 → 96,35 cheveux par cm²Voir la citationGroup 1 83.80 ± 12.83 96.35 ± 16.02 p < 0.01 Citation complémentaire (methode) baseline to Week 24. We photographed the same 1 cm2 areas that were the most fixed anterior parietal area (the intersection of the front edge of the two ears and the midline of the top of the head) by FPHL with the contact dome of the camera applied to the head, using dermoscopy (Dermlite 3 gen DL3N, California, USA). Then, we calcu- lated the amount of hair in the area through the dermoscopy picture. Citation complémentaire (significativite) p value p = 0.88 p < 0.01 Zhang Y, Sheng Y, Zeng Y et al.. Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population. Journal of Cosmetic Dermatology 2022, DOI 10.1111/jocd.15424. Citation sous licence CC-BY. | 84,5 → 121,9 cheveux par cm²Voir la citationGroup 2 84.50 ± 15.20 121.90 ± 19.47 p < 0.01 Citation complémentaire (methode) baseline to Week 24. We photographed the same 1 cm2 areas that were the most fixed anterior parietal area (the intersection of the front edge of the two ears and the midline of the top of the head) by FPHL with the contact dome of the camera applied to the head, using dermoscopy (Dermlite 3 gen DL3N, California, USA). Then, we calcu- lated the amount of hair in the area through the dermoscopy picture. Citation complémentaire (significativite) p value p = 0.88 p < 0.01 Zhang Y, Sheng Y, Zeng Y et al.. Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population. Journal of Cosmetic Dermatology 2022, DOI 10.1111/jocd.15424. Citation sous licence CC-BY. | Probablement réel |
| Patients améliorés (évaluation investigateur) | 45 % (9 sur 20)Voir la citationGroup 1 11 9 45% Citation complémentaire (significativite) Based on the principle that a reduction in the Sinclair scale of one grade or more was considered clinically effective. The clinical efficacy of the two groups at session 24 is shown in Table 3. The proportion of effective patients in group 2 was 85%, which was sig- nificantly higher than that in group 1 (p < 0.01) (Table 3). Zhang Y, Sheng Y, Zeng Y et al.. Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population. Journal of Cosmetic Dermatology 2022, DOI 10.1111/jocd.15424. Citation sous licence CC-BY. | 85 % (17 sur 20)Voir la citationBased on the principle that a reduction in the Sinclair scale of one grade or more was considered clinically effective. The clinical efficacy of the two groups at session 24 is shown in Table 3. The proportion of effective patients in group 2 was 85%, which was sig- nificantly higher than that in group 1 (p < 0.01) (Table 3). Citation complémentaire (valeur) Group 2 3 17 85% Zhang Y, Sheng Y, Zeng Y et al.. Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population. Journal of Cosmetic Dermatology 2022, DOI 10.1111/jocd.15424. Citation sous licence CC-BY. | Probablement réel |
| Incidence d'une pilosité accrue | 3 sur 20Voir la citationTwo patients in group 2 experienced an occasional headache on the day after the first two sessions of MN treatment, but they were tolerated without affecting life. The symptoms disappeared the next day. Ten patients in group 2 experienced hairy symptoms in other parts of the body during the treatment period, such as the forearm, fingers, or around the lips, while three patients in group 1 reported the same symptoms. There were seven patients in group 1 who experienced scalp itching and a transient increase in hair loss Zhang Y, Sheng Y, Zeng Y et al.. Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population. Journal of Cosmetic Dermatology 2022, DOI 10.1111/jocd.15424. Citation sous licence CC-BY. | 10 sur 20Voir la citationTwo patients in group 2 experienced an occasional headache on the day after the first two sessions of MN treatment, but they were tolerated without affecting life. The symptoms disappeared the next day. Ten patients in group 2 experienced hairy symptoms in other parts of the body during the treatment period, such as the forearm, fingers, or around the lips, while three patients in group 1 reported the same symptoms. There were seven patients in group 1 who experienced scalp itching and a transient increase in hair loss Zhang Y, Sheng Y, Zeng Y et al.. Randomized trial of microneedling combined with 2% minoxidil topical solution for the treatment of female pattern hair loss in a Chinese population. Journal of Cosmetic Dermatology 2022, DOI 10.1111/jocd.15424. Citation sous licence CC-BY. | Non testé |