Plasma riche en plaquettes + Procapil, concentration non précisée
1 étude, 54 participants · Alopécie androgénétique · Hommes
Associé au plasma riche en plaquettes, le Procapil (concentration non précisée) obtient de moins bons résultats que le PRP associé à redensyl, Serenoa repens et biotine, dans un seul essai de solidité moyenne chez 54 hommes atteints d'alopécie androgénétique (Tr 2023). À 15 semaines, la note d'évolution sur photos atteint 1,48 point contre 2,03, 18,5 % des hommes changent de stade contre 25,9 %, et 25,9 % se disent très satisfaits contre 44,4 %. Côté tolérance, 5 hommes sur 27 ont des démangeaisons et 4 sur 27 un eczéma de contact, contre 3 sur 27 pour chacun avec l'autre association. Ce sont des indices, à confirmer.
Piste explorée
Ce traitement n'a été mesuré que dans une seule étude par critère : il n'existe pas encore assez d'essais pour en tirer une conclusion. Les résultats ci-dessous sont des indices, à lire avec leurs limites.
Les résultats
Critères mesurés dans une seule étude : chaque ligne est un résultat isolé.
Efficacité
- Patients gagnant un grade de Norwood-Hamilton18,5 % (5 sur 27) face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
In group A, 18.5% (n = 5) of the patients had a significant reduction in AGA grading based on the Norwood- Hamilton classification, whereas 25.9% (n = 7) of patients in group B showed a significant reduction in AGA grading based on the Norwood-Hamilton classification.
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
- Patients très satisfaits25,9 % (7 sur 27) face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
Patient satisfaction was assessed in both treatment modalities using a visual analog scale at the end of the second follow-up; 25.9% (n = 7) in group A and 44.4% (n = 12) in group B showed a VAS score of more than or equal to (≥) 8. The mean VAS of group A and group B were 6.8 and 7.4, respectively. These results are statistically significant.
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
- Patients à plus de 75 % d'amélioration7,4 % (2 sur 27) face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
assessed using the GPA scale at the end of the second follow-up, 3 of 7 7.4% (n = 2) and 22.2% (n = 6) showed a score of 3 (>75% improvement) in group A and group B, respectively. Table 4 shows the results of the GPA scale where the values are statistically significant.
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
- Satisfaction du patient6,8 points face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
Patient satisfaction was assessed in both treatment modalities using a visual analog scale at the end of the second follow-up; 25.9% (n = 7) in group A and 44.4% (n = 12) in group B showed a VAS score of more than or equal to (≥) 8. The mean VAS of group A and group B were 6.8 and 7.4, respectively. These results are statistically significant.
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
- Score d'évaluation photographique globale1,44 points face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
1 2 3 Group A 0 0.44 0.81 Group B 0 0.51 1 P-value <0.00001 <0.00001 TABLE 4: Efficacy assessed using the GPA 4 FU1 FU2 1.22 1.44 1.48 1.42 1.73 2.03 <0.00001 <0.00001 <0.00001
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
- Score d'évaluation photographique globale1,48 points face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
1 2 3 Group A 0 0.44 0.81 Group B 0 0.51 1 P-value <0.00001 <0.00001 TABLE 4: Efficacy assessed using the GPA 4 FU1 FU2 1.22 1.44 1.48 1.42 1.73 2.03 <0.00001 <0.00001 <0.00001
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
Tolérance
- Dermatite de contact4 sur 27 face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
No side effects Pruritus Group A 16 5 Group B 18 3 Total 34 (63%) 8 (14.8%) TABLE 5: Side effects Figure 1 shows the efficacy Seborrheic dermatitis Allergic contact dermatitis 2 4 3 3 5 (9.2%) 7 (13%)
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
- Dermatite séborrhéique2 sur 27 face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
No side effects Pruritus Group A 16 5 Group B 18 3 Total 34 (63%) 8 (14.8%) TABLE 5: Side effects Figure 1 shows the efficacy Seborrheic dermatitis Allergic contact dermatitis 2 4 3 3 5 (9.2%) 7 (13%)
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
- Prurit5 sur 27 face à Plasma riche en plaquettes + redensyl, Serenoa repens et biotine
Voir la citation
No side effects Pruritus Group A 16 5 Group B 18 3 Total 34 (63%) 8 (14.8%) TABLE 5: Side effects Figure 1 shows the efficacy Seborrheic dermatitis Allergic contact dermatitis 2 4 3 3 5 (9.2%) 7 (13%)
Citation complémentaire (inclusion)
Participants were required to participate in serial global photography at baseline and at subsequent PRP sessions. A third observer assessed the treatment efficacy based on the global photographic assessment (GPA) scale during which lighting and position were identical. Scores of 0, 1, 2, and 3 were assigned by the third observer for <25%, 26%-50%, 51%-75%, and >75% improvement, respectively. Clinical assessment of AGA was performed using the Norwood-Hamilton classification for men (grades I to VII) at baseline and at subsequent visits for PRP treatment every three weeks for all four sessions. Follow-up was done at the end of the third and sixth week after the completion of the therapy, and side effects were noted. A visual analog scale (VAS) (scores from 0 to 10) was used to assess the participants’ perceived satisfaction with the treatment at the end of the second follow-up.
Citation complémentaire (methode)
A total of 54 AGA patients were randomized into two equal groups, group A and group B (27 individuals in each group), using a computer-generated block randomization from www.randomization.com [9]. Group A included patients treated with topical Procapil with PRP therapy, and group B included patients treated with topical RSB with PRP therapy. Patients in both groups were treated with four sessions of appropriate therapy at three-week intervals and were followed up at the end of the third and sixth weeks. Group A patients received PRP once every three weeks and applied 1 mL of topical Procapil daily. Patients in group B received PRP once every three weeks and applied 1 mL topical combination of redensyl, saw palmetto, and biotin once daily.
Tr P, Ts R, K SK et al.. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia. Cureus 2023, DOI 10.7759/cureus.38696. Citation sous licence CC-BY.
Les études
- Tr 2023 · Essai randomisé, risque de biais modéré. A comparative study of topical Procapil with platelet-rich plasma therapy versus topical redensyl, saw palmetto, and biotin with platelet-rich plasma therapy in the treatment of androgenetic alopecia