Huile de graine de courge 400 mg par jour (Octa Sabal Plus)
1 étude, 76 participants · Alopécie androgénétique · Hommes
Chez l'homme, l'huile de graine de courge à 400 mg par jour s'accompagne d'un gain de densité de +40 % en 24 semaines, nettement plus que le placebo (Cho 2014), et les patients se jugent davantage améliorés (3,4 points). L'épaisseur du cheveu, elle, ne progresse pas plus que sous placebo. Côté tolérance, un patient signale des démangeaisons et un autre une gêne digestive. Ces résultats viennent d'un seul essai de fiabilité moyenne, chez 76 hommes : des indices, à confirmer.
Piste explorée
Ce traitement n'a été mesuré que dans une seule étude par critère : il n'existe pas encore assez d'essais pour en tirer une conclusion. Les résultats ci-dessous sont des indices, à lire avec leurs limites.
Les résultats
Critères mesurés dans une seule étude : chaque ligne est un résultat isolé.
Efficacité
- Auto-évaluation du patient3,4 points face à Placebo
Voir la citation
growth at 12 weeks. However, after 24 weeks, the self-rated improvementscoreintheinterventiongroupwashigherthan inthecontrolgroup(3.4±2.9intheinterventiongroupversus 2.1±2.0inthecontrolgroup,mean±SD),andthisdifference was significantly different (𝑃 = 0.013 by the two sample 𝑡-test).
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Gain de diamètre depuis le départsans valeur publiée face à Placebo
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versus 1.8 ± 6.2; 𝑃 = 0.004). However, changes in hair thicknessduring24weeksweresimilarinthegroups(Δhair thickness per field of view using a ×150 lens; 0.34 ± 0.03 versus0.34±0.02;𝑃=0.991).At12and24weeks,therewere
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Patients améliorés (évaluation investigateur)17 patients face à Placebo
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wereratedasunchangedrelativetobaselineand44.1%(17/37) Online were rated as slightly or moderately improved (Figure2).
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Citation complémentaire (significativite)
intergroup differences (data not shown, 𝑃 = 0.002 by chi-
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Patients dont l'état s'est aggravé2,7 % face à Placebo
Voir la citation
At 24 weeks, 2.7% (1/37) of subjects in the intervention group were assessed to have worsenedbyblindedinvestigatorassessments;51.4%(19/37)
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Citation complémentaire (significativite)
intergroup differences (data not shown, 𝑃 = 0.002 by chi-
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Patients stabilisés, sans gain ni perte51,4 % face à Placebo
Voir la citation
worsenedbyblindedinvestigatorassessments;51.4%(19/37)
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Citation complémentaire (significativite)
intergroup differences (data not shown, 𝑃 = 0.002 by chi-
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Satisfaction du patient3,5 points face à Placebo
Voir la citation
In addition, group self-rated satisfaction scoreswerealsosignificantlydifferentat24weeks(3.5±2.9in theinterventiongroupversus2.3±2.0inthecontrolgroup, 𝑃=0.003)(Table3).
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Variation relative de densité+30 % face à Placebo
Voir la citation
30% and 40% mean increases in hair counts from baseline inPSO-treatedmenand5%and10%increasesinhaircount in placebo-treated men, which resulted in significant net increaseof25%and30%(both,𝑃 < 0.001)atweeks12and 24,respectively,intheinterventiongroupascomparedwith theplacebogroup(Figure3).
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Variation relative de densité+40 % face à Placebo
Voir la citation
30% and 40% mean increases in hair counts from baseline inPSO-treatedmenand5%and10%increasesinhaircount in placebo-treated men, which resulted in significant net increaseof25%and30%(both,𝑃 < 0.001)atweeks12and 24,respectively,intheinterventiongroupascomparedwith theplacebogroup(Figure3).
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
Tolérance
- Prurit généralisé1 patient face à Placebo
Voir la citation
3.5.Safety. Mostofthesubjectscompletedtheprotocolwith- outadversesymptoms.Onesubjectintheinterventiongroup andonesubjectinthecontrolgroupcomplainedofawhole bodyitchingsensation.Onesubjectintheinterventiongroup complained of mild abdominal discomfort. No changes in
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
- Troubles digestifs1 patient face à Placebo
Voir la citation
3.5.Safety. Mostofthesubjectscompletedtheprotocolwith- outadversesymptoms.Onesubjectintheinterventiongroup andonesubjectinthecontrolgroupcomplainedofawhole bodyitchingsensation.Onesubjectintheinterventiongroup complained of mild abdominal discomfort. No changes in
Citation complémentaire (inclusion)
as the Norwood-Hamilton type II, III, III Vertex, IV, and V [13]. Ninety adults between the ages of 20 and 65 years with mild to moderate AGA were initially enrolled at a
Cho YH, Lee SY, Jeong DW et al.. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evidence-Based Complementary and Alternative Medicine 2014, DOI 10.1155/2014/549721. Citation sous licence CC-BY.
Les études
- Cho 2014 · Essai randomisé, risque de biais modéré. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial