Plasma riche en plaquettes, 4 séances
3 études, 250 participants · Alopécie androgénétique · Pelade · Femmes · Hommes
Trois études de fiabilité limitée ont testé 4 séances de plasma riche en plaquettes (PRP), selon des protocoles différents. Dans l'alopécie androgénétique, chez 30 femmes, 4 séances hebdomadaires de PRP activé font mieux que le placebo, comparé sur une autre zone du crâne, pour le nombre de cheveux et leur épaisseur à 30 semaines, des écarts probablement réels ; la chute s'arrête chez 25 patientes sur 30 (Tawfik 2018). Chez 160 hommes, le PRP seul fait moins bien que le PRP associé au Procapil 5 % : à 26 semaines, 10 % sont très satisfaits contre 13,75 %, un écart probablement réel (Khoso 2024). Dans la pelade, des injections mensuelles dans les plaques font moins bien que la triamcinolone injectée : 73 % des patients améliorés contre 90 % à 16 semaines, un écart probablement réel, mais qui peut être dû au hasard dans chaque niveau de sévérité (Khan 2022).
Piste explorée
Ce traitement n'a été mesuré que dans une seule étude par critère : il n'existe pas encore assez d'essais pour en tirer une conclusion. Les résultats ci-dessous sont des indices, à lire avec leurs limites.
Les résultats
Critères mesurés dans une seule étude : chaque ligne est un résultat isolé.
Efficacité
- Amélioration marquée11,25 % face à Plasma riche en plaquettes, 4 séances + Procapil 5 %
Voir la citation
Similarly, based on Dermatologist evaluation 11.25%,16.25% & 30% in Group A and 15%, 23,75% & 38.75% of patients in Group B were in the Excellent, Moderate and Slight Hair regrowth range respectively (p-value=0.0069), Figure-3.
Citation complémentaire (inclusion)
All male patients with hair loss (Hamilton score II -V), between the ages 18–50 years and willing to undergo the procedure were included in this study
Citation complémentaire (methode)
syringes were used to inject it intradermally. Group A received four sessions of PRP 4 weeks apart while group B received the same therapy in combination with 5% topical Procapil solution,5 puffs twice a day for 6 months. Basic demographic
Khoso H, Fahim M. Comparison of platelet rich therapy alone with platelet rich therapy along with daily topical 5% procapil application for the treatment of androgenetic alopecia. Journal of Ayub Medical College Abbottabad 2024, DOI 10.55519/JAMC-02-12749. Citation sous licence CC-BY-ND.
- Densité capillaire totale activé, séances hebdomadairessans valeur publiée face à Placebo
Voir la citation
Results: There was a statistical significant difference between PRP and placebo areas(P<.005)regardingbothhairdensityandhairthicknessasmeasuredbyafollis-
Tawfik AA, Osman MAR. The effect of autologous activated platelet-rich plasma injection on female pattern hair loss: a randomized placebo-controlled study. Journal of Cosmetic Dermatology 2018, DOI 10.1111/jocd.12357. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Diamètre de la tige pilaire activé, séances hebdomadairessans valeur publiée face à Placebo
Voir la citation
Results: There was a statistical significant difference between PRP and placebo areas(P<.005)regardingbothhairdensityandhairthicknessasmeasuredbyafollis-
Tawfik AA, Osman MAR. The effect of autologous activated platelet-rich plasma injection on female pattern hair loss: a randomized placebo-controlled study. Journal of Cosmetic Dermatology 2018, DOI 10.1111/jocd.12357. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Patients améliorés (évaluation investigateur) intralésionnel, séances mensuelles73 % face à Triamcinolone intralésionnel, concentration non précisée
Voir la citation
Efficacy among two groups revealed that 27 (90%) patients of Group A had effective treatment response (p<0.05) while 3 (10%) of patients didn’t show marked improvement. In Group B 22 (73%) showed effective response (p=0.05) while 8 (27%) patients didn’t show significant improvement to the treatment.
Citation complémentaire (inclusion)
Patients with mild to moderate alopecia areata of both sexes were included in the study. Their age limit was ranging from 14 to 25 years. Before participating in the study patients were off the J Ayub Med Coll Abbottabad 2022;34(4) treatment for about three months, i.e., from February 2021. Alopecia areata is defined as three or fewer patches of alopecia with a diameter of at least 3 cm. Moderate alopecia areata is the presence of more than three patches or patches greater than 3cm diameter without alopecia totalis or alopecia universalis.7
Citation complémentaire (methode)
Photographs were taken before and after 4,8,12, and 16 weeks of treatment in order to assess treatment response and to compare efficacy between intralesional injection of triamcinolone and platelet rich plasma. In each follow-up, the percentage of hair regrowth was assessed by using SALT SCORE.
Khan FA, Hussain M, Khan BM et al.. Comparative study between intralesional injection of platelet rich plasma and intra lesional triamcinolone for the treatment of alopecia areata. Journal of Ayub Medical College Abbottabad 2022. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Patients améliorés (évaluation investigateur) pelade legere, score de severite 1 a 2 intralésionnel, séances mensuelles11 patients face à Triamcinolone intralésionnel, concentration non précisée
Voir la citation
Table-2: Stratification of efficacy with respect to severity score Severity score Efficacy Group A Group B *p-value 1-2 (mild) Effective 15 11 0.1224 Not effective 1 4 Total 16 15 3-4 (moderate) Effective 12 11 0.4108 Not effective 2 4 Total 14 15
Citation complémentaire (inclusion)
Patients with mild to moderate alopecia areata of both sexes were included in the study. Their age limit was ranging from 14 to 25 years. Before participating in the study patients were off the J Ayub Med Coll Abbottabad 2022;34(4) treatment for about three months, i.e., from February 2021. Alopecia areata is defined as three or fewer patches of alopecia with a diameter of at least 3 cm. Moderate alopecia areata is the presence of more than three patches or patches greater than 3cm diameter without alopecia totalis or alopecia universalis.7
Citation complémentaire (methode)
Photographs were taken before and after 4,8,12, and 16 weeks of treatment in order to assess treatment response and to compare efficacy between intralesional injection of triamcinolone and platelet rich plasma. In each follow-up, the percentage of hair regrowth was assessed by using SALT SCORE.
Khan FA, Hussain M, Khan BM et al.. Comparative study between intralesional injection of platelet rich plasma and intra lesional triamcinolone for the treatment of alopecia areata. Journal of Ayub Medical College Abbottabad 2022. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Patients améliorés (évaluation investigateur) pelade moderee, score de severite 3 a 4 intralésionnel, séances mensuelles11 patients face à Triamcinolone intralésionnel, concentration non précisée
Voir la citation
Table-2: Stratification of efficacy with respect to severity score Severity score Efficacy Group A Group B *p-value 1-2 (mild) Effective 15 11 0.1224 Not effective 1 4 Total 16 15 3-4 (moderate) Effective 12 11 0.4108 Not effective 2 4 Total 14 15
Citation complémentaire (inclusion)
Patients with mild to moderate alopecia areata of both sexes were included in the study. Their age limit was ranging from 14 to 25 years. Before participating in the study patients were off the J Ayub Med Coll Abbottabad 2022;34(4) treatment for about three months, i.e., from February 2021. Alopecia areata is defined as three or fewer patches of alopecia with a diameter of at least 3 cm. Moderate alopecia areata is the presence of more than three patches or patches greater than 3cm diameter without alopecia totalis or alopecia universalis.7
Citation complémentaire (methode)
Photographs were taken before and after 4,8,12, and 16 weeks of treatment in order to assess treatment response and to compare efficacy between intralesional injection of triamcinolone and platelet rich plasma. In each follow-up, the percentage of hair regrowth was assessed by using SALT SCORE.
Khan FA, Hussain M, Khan BM et al.. Comparative study between intralesional injection of platelet rich plasma and intra lesional triamcinolone for the treatment of alopecia areata. Journal of Ayub Medical College Abbottabad 2022. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Patients en amélioration légère (échelle médecin, +1)30 % face à Plasma riche en plaquettes, 4 séances + Procapil 5 %
Voir la citation
Similarly, based on Dermatologist evaluation 11.25%,16.25% & 30% in Group A and 15%, 23,75% & 38.75% of patients in Group B were in the Excellent, Moderate and Slight Hair regrowth range respectively (p-value=0.0069), Figure-3.
Citation complémentaire (inclusion)
All male patients with hair loss (Hamilton score II -V), between the ages 18–50 years and willing to undergo the procedure were included in this study
Citation complémentaire (methode)
syringes were used to inject it intradermally. Group A received four sessions of PRP 4 weeks apart while group B received the same therapy in combination with 5% topical Procapil solution,5 puffs twice a day for 6 months. Basic demographic
Khoso H, Fahim M. Comparison of platelet rich therapy alone with platelet rich therapy along with daily topical 5% procapil application for the treatment of androgenetic alopecia. Journal of Ayub Medical College Abbottabad 2024, DOI 10.55519/JAMC-02-12749. Citation sous licence CC-BY-ND.
- Patients en amélioration modérée (échelle médecin, +2)16,25 % face à Plasma riche en plaquettes, 4 séances + Procapil 5 %
Voir la citation
Similarly, based on Dermatologist evaluation 11.25%,16.25% & 30% in Group A and 15%, 23,75% & 38.75% of patients in Group B were in the Excellent, Moderate and Slight Hair regrowth range respectively (p-value=0.0069), Figure-3.
Citation complémentaire (inclusion)
All male patients with hair loss (Hamilton score II -V), between the ages 18–50 years and willing to undergo the procedure were included in this study
Citation complémentaire (methode)
syringes were used to inject it intradermally. Group A received four sessions of PRP 4 weeks apart while group B received the same therapy in combination with 5% topical Procapil solution,5 puffs twice a day for 6 months. Basic demographic
Khoso H, Fahim M. Comparison of platelet rich therapy alone with platelet rich therapy along with daily topical 5% procapil application for the treatment of androgenetic alopecia. Journal of Ayub Medical College Abbottabad 2024, DOI 10.55519/JAMC-02-12749. Citation sous licence CC-BY-ND.
- Patients légèrement satisfaits25 % face à Plasma riche en plaquettes, 4 séances + Procapil 5 %
Voir la citation
More than 47% of patients had positive family history. After 6 months 25%,13.75% and 10% of patients in Group A were in the Slight, Moderate and very satisfactory range. On the other hand, in Group B the Slight, Moderate and very satisfactory categories consisted of 35% 23.75% and 13.75% patients (p-value=0.0022), Figure-2.
Citation complémentaire (inclusion)
All male patients with hair loss (Hamilton score II -V), between the ages 18–50 years and willing to undergo the procedure were included in this study
Citation complémentaire (methode)
syringes were used to inject it intradermally. Group A received four sessions of PRP 4 weeks apart while group B received the same therapy in combination with 5% topical Procapil solution,5 puffs twice a day for 6 months. Basic demographic
Khoso H, Fahim M. Comparison of platelet rich therapy alone with platelet rich therapy along with daily topical 5% procapil application for the treatment of androgenetic alopecia. Journal of Ayub Medical College Abbottabad 2024, DOI 10.55519/JAMC-02-12749. Citation sous licence CC-BY-ND.
- Patients moyennement satisfaits13,75 % face à Plasma riche en plaquettes, 4 séances + Procapil 5 %
Voir la citation
More than 47% of patients had positive family history. After 6 months 25%,13.75% and 10% of patients in Group A were in the Slight, Moderate and very satisfactory range. On the other hand, in Group B the Slight, Moderate and very satisfactory categories consisted of 35% 23.75% and 13.75% patients (p-value=0.0022), Figure-2.
Citation complémentaire (inclusion)
All male patients with hair loss (Hamilton score II -V), between the ages 18–50 years and willing to undergo the procedure were included in this study
Citation complémentaire (methode)
syringes were used to inject it intradermally. Group A received four sessions of PRP 4 weeks apart while group B received the same therapy in combination with 5% topical Procapil solution,5 puffs twice a day for 6 months. Basic demographic
Khoso H, Fahim M. Comparison of platelet rich therapy alone with platelet rich therapy along with daily topical 5% procapil application for the treatment of androgenetic alopecia. Journal of Ayub Medical College Abbottabad 2024, DOI 10.55519/JAMC-02-12749. Citation sous licence CC-BY-ND.
- Patients sans réponse au traitement intralésionnel, séances mensuelles27 % face à Triamcinolone intralésionnel, concentration non précisée
Voir la citation
Efficacy among two groups revealed that 27 (90%) patients of Group A had effective treatment response (p<0.05) while 3 (10%) of patients didn’t show marked improvement. In Group B 22 (73%) showed effective response (p=0.05) while 8 (27%) patients didn’t show significant improvement to the treatment.
Citation complémentaire (inclusion)
Patients with mild to moderate alopecia areata of both sexes were included in the study. Their age limit was ranging from 14 to 25 years. Before participating in the study patients were off the J Ayub Med Coll Abbottabad 2022;34(4) treatment for about three months, i.e., from February 2021. Alopecia areata is defined as three or fewer patches of alopecia with a diameter of at least 3 cm. Moderate alopecia areata is the presence of more than three patches or patches greater than 3cm diameter without alopecia totalis or alopecia universalis.7
Citation complémentaire (methode)
Photographs were taken before and after 4,8,12, and 16 weeks of treatment in order to assess treatment response and to compare efficacy between intralesional injection of triamcinolone and platelet rich plasma. In each follow-up, the percentage of hair regrowth was assessed by using SALT SCORE.
Khan FA, Hussain M, Khan BM et al.. Comparative study between intralesional injection of platelet rich plasma and intra lesional triamcinolone for the treatment of alopecia areata. Journal of Ayub Medical College Abbottabad 2022. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Patients très satisfaits10 % face à Plasma riche en plaquettes, 4 séances + Procapil 5 %
Voir la citation
More than 47% of patients had positive family history. After 6 months 25%,13.75% and 10% of patients in Group A were in the Slight, Moderate and very satisfactory range. On the other hand, in Group B the Slight, Moderate and very satisfactory categories consisted of 35% 23.75% and 13.75% patients (p-value=0.0022), Figure-2.
Citation complémentaire (inclusion)
All male patients with hair loss (Hamilton score II -V), between the ages 18–50 years and willing to undergo the procedure were included in this study
Citation complémentaire (methode)
syringes were used to inject it intradermally. Group A received four sessions of PRP 4 weeks apart while group B received the same therapy in combination with 5% topical Procapil solution,5 puffs twice a day for 6 months. Basic demographic
Khoso H, Fahim M. Comparison of platelet rich therapy alone with platelet rich therapy along with daily topical 5% procapil application for the treatment of androgenetic alopecia. Journal of Ayub Medical College Abbottabad 2024, DOI 10.55519/JAMC-02-12749. Citation sous licence CC-BY-ND.
- Test de traction devenu négatif activé, séances hebdomadaires83 % (25 sur 30)
Voir la citation
cope. The hair pull test became negative in PRP-injected areas in 25 patients (83%)
Tawfik AA, Osman MAR. The effect of autologous activated platelet-rich plasma injection on female pattern hair loss: a randomized placebo-controlled study. Journal of Cosmetic Dermatology 2018, DOI 10.1111/jocd.12357. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
Comparé directement à
Traitements testés contre celui-ci dans un même essai, sur les mêmes patients.
Les études
- Tawfik 2018 · Essai randomisé, risque de biais élevé. The effect of autologous activated platelet-rich plasma injection on female pattern hair loss: a randomized placebo-controlled study
- Khan 2022 · Essai randomisé, risque de biais élevé. Comparative study between intralesional injection of platelet rich plasma and intra lesional triamcinolone for the treatment of alopecia areata
- Khoso 2024 · Étude de cohorte, risque de biais élevé. Comparison of platelet rich therapy alone with platelet rich therapy along with daily topical 5% procapil application for the treatment of androgenetic alopecia