Finastéride topique 0,25 % face à Minoxidil 5 % le matin + finastéride topique 0,25 % le soir
1 essai les comparent directement, sur les mêmes patients. Voir Finastéride topique 0,25 % · Voir Minoxidil 5 % le matin + finastéride topique 0,25 % le soir
Ajouter le minoxidil 5 % le matin au finastéride topique 0,25 % du soir fait nettement mieux que le finastéride topique seul, chez des hommes de 24 ans en moyenne (Rossi 2024). À 26 semaines, la densité passe de 101,9 à 183,5 cheveux par cm² avec l'association, contre de 136,6 à 154,6 sous finastéride seul, et 79 % des hommes (15 sur 19) sont nettement améliorés contre 8 % (1 sur 12), sans que ce dernier écart soit testé. Ces résultats viennent d'un seul petit essai de fiabilité limitée.
Rossi 2024
Essai randomisé, risque de biais élevé. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial
| Critère | Finastéride topique 0,25 % | Minoxidil 5 % le matin + finastéride topique 0,25 % le soir | Écart |
|---|---|---|---|
| Amélioration marquée | 8 % (1 sur 12)Voir la citationpercentage of subjects in Group A achieved a GPAS score of ≥2 in comparison with Groups B and C after both 3 and 6 months (month by the 3: 84% vs. 8% and 45%; month 6: 79% vs. 8% and 41%, respectively). Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | 84 % (16 sur 19)Voir la citationpercentage of subjects in Group A achieved a GPAS score of ≥2 in comparison with Groups B and C after both 3 and 6 months (month by the 3: 84% vs. 8% and 45%; month 6: 79% vs. 8% and 41%, respectively). Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | Non testé |
| Amélioration marquée | 8 % (1 sur 12)Voir la citationpercentage of subjects in Group A achieved a GPAS score of ≥2 in comparison with Groups B and C after both 3 and 6 months (month by the 3: 84% vs. 8% and 45%; month 6: 79% vs. 8% and 41%, respectively). Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | 79 % (15 sur 19)Voir la citationpercentage of subjects in Group A achieved a GPAS score of ≥2 in comparison with Groups B and C after both 3 and 6 months (month by the 3: 84% vs. 8% and 45%; month 6: 79% vs. 8% and 41%, respectively). Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | Non testé |
| Densité capillaire totale | 136,6 → 149,5 cheveux par cm²Voir la citationdensity over time (158.2 12.5 and 183.5 15.3 hair/cm2 at T3 and ± ± T6 for Group A, 149.5 14.3 and 154.6 18.6 hair/cm2 at T3 and ± ± T6 for Group B, and 212.3 18.4 and 223.7 19.8 hair/cm2 at T3 ± ± and T6 for Group C) although it was statistically significant only in group A (Figure 2). The mean change in hair density from baseline was statistically different between group A (MNX F) and group B + (F) (p < 0.01) but no statistical differences were observed between group A (MNX F) and group C (MNX), both after 3 and 6 months. Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Citation complémentaire (valeur) At baseline, mean ± SE hair density was 101.9 ± 13.4, 136.6 ± 13.9, on and 185.0 16.7 hair/cm2, for group A (MNX F), group B (F), and Wiley ± + Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | 101,9 → 158,2 cheveux par cm²Voir la citationdensity over time (158.2 12.5 and 183.5 15.3 hair/cm2 at T3 and ± ± T6 for Group A, 149.5 14.3 and 154.6 18.6 hair/cm2 at T3 and ± ± T6 for Group B, and 212.3 18.4 and 223.7 19.8 hair/cm2 at T3 ± ± and T6 for Group C) although it was statistically significant only in group A (Figure 2). The mean change in hair density from baseline was statistically different between group A (MNX F) and group B + (F) (p < 0.01) but no statistical differences were observed between group A (MNX F) and group C (MNX), both after 3 and 6 months. Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Citation complémentaire (valeur) At baseline, mean ± SE hair density was 101.9 ± 13.4, 136.6 ± 13.9, on and 185.0 16.7 hair/cm2, for group A (MNX F), group B (F), and Wiley ± + Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | Probablement réel |
| Densité capillaire totale | 136,6 → 154,6 cheveux par cm²Voir la citationdensity over time (158.2 12.5 and 183.5 15.3 hair/cm2 at T3 and ± ± T6 for Group A, 149.5 14.3 and 154.6 18.6 hair/cm2 at T3 and ± ± T6 for Group B, and 212.3 18.4 and 223.7 19.8 hair/cm2 at T3 ± ± and T6 for Group C) although it was statistically significant only in group A (Figure 2). The mean change in hair density from baseline was statistically different between group A (MNX F) and group B + (F) (p < 0.01) but no statistical differences were observed between group A (MNX F) and group C (MNX), both after 3 and 6 months. Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Citation complémentaire (valeur) At baseline, mean ± SE hair density was 101.9 ± 13.4, 136.6 ± 13.9, on and 185.0 16.7 hair/cm2, for group A (MNX F), group B (F), and Wiley ± + Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | 101,9 → 183,5 cheveux par cm²Voir la citationdensity over time (158.2 12.5 and 183.5 15.3 hair/cm2 at T3 and ± ± T6 for Group A, 149.5 14.3 and 154.6 18.6 hair/cm2 at T3 and ± ± T6 for Group B, and 212.3 18.4 and 223.7 19.8 hair/cm2 at T3 ± ± and T6 for Group C) although it was statistically significant only in group A (Figure 2). The mean change in hair density from baseline was statistically different between group A (MNX F) and group B + (F) (p < 0.01) but no statistical differences were observed between group A (MNX F) and group C (MNX), both after 3 and 6 months. Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Citation complémentaire (valeur) At baseline, mean ± SE hair density was 101.9 ± 13.4, 136.6 ± 13.9, on and 185.0 16.7 hair/cm2, for group A (MNX F), group B (F), and Wiley ± + Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | Probablement réel |
| Évolution sur une échelle à 7 points (de -3 à +3) | +0,6 pointsVoir la citationThe global photographic assessment score (GPAS) was sig- use; OA nificantly higher in Group A compared to Group B (p < 0.001) and articles Group C (p 0.05), both at 3 and 6 months (2.0 0.7 vs. 0.6 0.8 and < ± ± are 1.3 ± 0.6; respectively at month 6) (Figure 5). A significantly greater Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | +2 pointsVoir la citationThe global photographic assessment score (GPAS) was sig- use; OA nificantly higher in Group A compared to Group B (p < 0.001) and articles Group C (p 0.05), both at 3 and 6 months (2.0 0.7 vs. 0.6 0.8 and < ± ± are 1.3 ± 0.6; respectively at month 6) (Figure 5). A significantly greater Citation complémentaire (inclusion) Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY. | Très probablement réel |