Minoxidil 5 % le matin + finastéride topique 0,25 % le soir
1 étude, 42 participants · Alopécie androgénétique · Hommes
Chez des hommes de 24 ans en moyenne atteints d'alopécie androgénétique, associer minoxidil 5 % le matin et finastéride topique 0,25 % le soir fait mieux que le finastéride topique seul (Rossi 2024) : en 26 semaines, la densité passe de 101,9 à 183,5 cheveux par cm², contre de 136,6 à 154,6, un écart significatif, avec aussi davantage de vrais cheveux, hors duvet. La note d'évolution, de -3 (forte perte) à +3 (forte repousse), atteint +2 points contre +0,6, et 79 % des hommes (15 sur 19) sont nettement améliorés contre 8 % (1 sur 12), sans que cet écart soit testé. Ces chiffres viennent d'un seul petit essai de fiabilité limitée, chez 42 hommes : des indices, à confirmer.
Piste explorée
Ce traitement n'a été mesuré que dans une seule étude par critère : il n'existe pas encore assez d'essais pour en tirer une conclusion. Les résultats ci-dessous sont des indices, à lire avec leurs limites.
Les résultats
Critères mesurés dans une seule étude : chaque ligne est un résultat isolé.
Efficacité
- Amélioration marquée84 % (16 sur 19) face à Finastéride topique 0,25 %
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percentage of subjects in Group A achieved a GPAS score of ≥2 in comparison with Groups B and C after both 3 and 6 months (month by the 3: 84% vs. 8% and 45%; month 6: 79% vs. 8% and 41%, respectively).
Citation complémentaire (inclusion)
Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was
Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY.
- Amélioration marquée79 % (15 sur 19) face à Finastéride topique 0,25 %
Voir la citation
percentage of subjects in Group A achieved a GPAS score of ≥2 in comparison with Groups B and C after both 3 and 6 months (month by the 3: 84% vs. 8% and 45%; month 6: 79% vs. 8% and 41%, respectively).
Citation complémentaire (inclusion)
Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was
Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY.
- Densité capillaire totale101,9 → 158,2 cheveux par cm² face à Finastéride topique 0,25 %
Voir la citation
density over time (158.2 12.5 and 183.5 15.3 hair/cm2 at T3 and ± ± T6 for Group A, 149.5 14.3 and 154.6 18.6 hair/cm2 at T3 and ± ± T6 for Group B, and 212.3 18.4 and 223.7 19.8 hair/cm2 at T3 ± ± and T6 for Group C) although it was statistically significant only in group A (Figure 2). The mean change in hair density from baseline was statistically different between group A (MNX F) and group B + (F) (p < 0.01) but no statistical differences were observed between group A (MNX F) and group C (MNX), both after 3 and 6 months.
Citation complémentaire (inclusion)
Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was
Citation complémentaire (valeur)
At baseline, mean ± SE hair density was 101.9 ± 13.4, 136.6 ± 13.9, on and 185.0 16.7 hair/cm2, for group A (MNX F), group B (F), and Wiley ± +
Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY.
- Densité capillaire totale101,9 → 183,5 cheveux par cm² face à Finastéride topique 0,25 %
Voir la citation
density over time (158.2 12.5 and 183.5 15.3 hair/cm2 at T3 and ± ± T6 for Group A, 149.5 14.3 and 154.6 18.6 hair/cm2 at T3 and ± ± T6 for Group B, and 212.3 18.4 and 223.7 19.8 hair/cm2 at T3 ± ± and T6 for Group C) although it was statistically significant only in group A (Figure 2). The mean change in hair density from baseline was statistically different between group A (MNX F) and group B + (F) (p < 0.01) but no statistical differences were observed between group A (MNX F) and group C (MNX), both after 3 and 6 months.
Citation complémentaire (inclusion)
Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was
Citation complémentaire (valeur)
At baseline, mean ± SE hair density was 101.9 ± 13.4, 136.6 ± 13.9, on and 185.0 16.7 hair/cm2, for group A (MNX F), group B (F), and Wiley ± +
Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY.
- Densité de cheveux terminauxsans valeur publiée face à Finastéride topique 0,25 %
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ever only in group A (Figure 3A). The mean change in hair terminal density from baseline was statistically different between group A (MNX + F) and group B (F) (p < 0.05) but no statistical differences were observed between group A (MNX + F) and group C (MNX), both after 3 and 6 months. On the contrary, although it was possible
Citation complémentaire (inclusion)
Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was
Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY.
- Diamètre de la tige pilairesans valeur publiée face à Minoxidil topique 5 %
Voir la citation
At baseline, mean ± SE hair diameter was 52.3 ± 3.1, 47.3 ± 2.1, Library and 42.0 ± 3.0 μm, for group A (MNX + F), group B (F), and group C (MNX), respectively. No statistical differences were observed be- for rules tween groups and during the treatment period (Figure 4).
Citation complémentaire (inclusion)
Patients and Methods: Forty- two males, mean age 24 ± 3 years, with AGA (I– VII of Norwood- Hamilton Grading Scale), treatment naive or free from any therapy for at least 6 months, were enrolled and randomly assigned to three arm treatment groups (2:1:1): group A (n = 19, the subjects applied 5% MNX in the morning and F spray in the evening), group B (n = 12, the subjects applied F spray in the evening), and group C (n = 11, the subjects applied 5% MNX twice daily). The efficacy of treatments was
Rossi A, Caro G. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial. Journal of Cosmetic Dermatology 2024, DOI 10.1111/jocd.15953. Citation sous licence CC-BY.
Comparé directement à
Traitements testés contre celui-ci dans un même essai, sur les mêmes patients.
- Finastéride topique 0,25 % 1 essai
- Minoxidil topique 5 % 1 essai
Les études
- Rossi 2024 · Essai randomisé, risque de biais élevé. Efficacy of the association of topical minoxidil and topical finasteride compared to their use in monotherapy in men with androgenetic alopecia: a prospective, randomized, controlled, assessor blinded, 3-arm, pilot trial