Minoxidil topique 2 % face à Minoxidil oral 0,25 mg
1 essai les comparent directement, sur les mêmes patients. Voir Minoxidil topique 2 % · Voir Minoxidil oral 0,25 mg
Chez 72 femmes atteintes d'alopécie androgénétique, un seul essai de fiabilité limitée (Vahabi-Amlashi 2021) a comparé la lotion de minoxidil 2 % au minoxidil oral 0,25 mg. Au bout de 39 semaines, le nombre de cheveux passe de 107,4 à 113,6 par cm² sous lotion et de 102 à 115,8 sous minoxidil oral, sans différence significative. Une pilosité accrue ailleurs sur le corps touche 8 % des femmes sous lotion et 7,7 % sous minoxidil oral, un point sur lequel les preuves sont jugées faibles.
Vahabi-Amlashi 2021
Essai randomisé, risque de biais élevé. A randomized clinical trial on therapeutic effects of 0.25 mg oral minoxidil tablets on treatment of female pattern hair loss.
| Critère | Minoxidil topique 2 % | Minoxidil oral 0,25 mg | Écart |
|---|---|---|---|
| Densité capillaire totale | 107,4 → 113,6 cheveux par cm²Voir la citationData were presented as Mean ± SD, Median * Based on the t-test or Mann-Whitney test. 2% Topical minoxidil Oral minoxidil 0.25 mg p value* solution 0.044±0.003 0.044±0.004 0.805 0.043 (0.035-0.052) 0.043 (0.033-0.056) 0.045±0.003 0.044±0.004 0.956 0.045 (0.035-0.052) 0.046 (0.036-0.056) 0.046±0.004 0.046±0.003 0.889 0.046 (0.036-0.055) 0.048 (0.040-0.050) 0.048±0.003 0.047±0.004 0.778 0.048 (0.042-0.052) 0.048 (0.040-0.052) 102.0±79.2 107.4±21.0 0.259 102.0 (84.0-144.0) 102.0 (60.0-156.0) 106.8±79.2 112.8±126 0.244 102.0 (84.0-144.0) 108.0 (60.0-156.0) 109.8±61.2 115.2±133.2 0.457 108.0 (96.0-132.0) 120.0 (72.0-156.0) 115.8±46.8 113.6±140.4 0.836 Citation complémentaire (methode) Table 1. Distribution of the hair diameter and density in oral minoxidil 0.25 mg versus topical 2% minoxidil solution for nine months in the treatment of FPHL. Before treatment 3rd month Hair diameter 6th month (mm) 9th month ITT analysis N=51 Before treatment 3rd month Hair density (per cm2) 6th month 9th month Vahabi-Amlashi S, Layegh P, Kiafar B et al.. A randomized clinical trial on therapeutic effects of 0.25 mg oral minoxidil tablets on treatment of female pattern hair loss.. Dermatol Ther 2021, DOI 10.1111/dth.15131. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | 102 → 115,8 cheveux par cm²Voir la citationData were presented as Mean ± SD, Median * Based on the t-test or Mann-Whitney test. 2% Topical minoxidil Oral minoxidil 0.25 mg p value* solution 0.044±0.003 0.044±0.004 0.805 0.043 (0.035-0.052) 0.043 (0.033-0.056) 0.045±0.003 0.044±0.004 0.956 0.045 (0.035-0.052) 0.046 (0.036-0.056) 0.046±0.004 0.046±0.003 0.889 0.046 (0.036-0.055) 0.048 (0.040-0.050) 0.048±0.003 0.047±0.004 0.778 0.048 (0.042-0.052) 0.048 (0.040-0.052) 102.0±79.2 107.4±21.0 0.259 102.0 (84.0-144.0) 102.0 (60.0-156.0) 106.8±79.2 112.8±126 0.244 102.0 (84.0-144.0) 108.0 (60.0-156.0) 109.8±61.2 115.2±133.2 0.457 108.0 (96.0-132.0) 120.0 (72.0-156.0) 115.8±46.8 113.6±140.4 0.836 Citation complémentaire (methode) Table 1. Distribution of the hair diameter and density in oral minoxidil 0.25 mg versus topical 2% minoxidil solution for nine months in the treatment of FPHL. Before treatment 3rd month Hair diameter 6th month (mm) 9th month ITT analysis N=51 Before treatment 3rd month Hair density (per cm2) 6th month 9th month Vahabi-Amlashi S, Layegh P, Kiafar B et al.. A randomized clinical trial on therapeutic effects of 0.25 mg oral minoxidil tablets on treatment of female pattern hair loss.. Dermatol Ther 2021, DOI 10.1111/dth.15131. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | Peut être dû au hasard |
| Incidence d'une pilosité accrue | 8 %Voir la citationAdverse effects The reported complications were included hirsutism, weight gain, gastrointestinal intolerance, and hypotension, which have not been significantly different in the two treatment groups. (p=0.444). In group 1 (oral minoxidil), two cases (7.7%) of hirsutism, one case (3.8%) of overweight of 4 kg have been observed that were mild and tolerable, and they completed their treatments. Also, two cases (7.7%) with gastrointestinal intolerance and one case of hypotension (3.8%) were excluded from the study. In group 2 (2% topical minoxidil), two cases (8%) of hirsutism have been observed, which was not severe, and no one was excluded due to it (Table 3). Vahabi-Amlashi S, Layegh P, Kiafar B et al.. A randomized clinical trial on therapeutic effects of 0.25 mg oral minoxidil tablets on treatment of female pattern hair loss.. Dermatol Ther 2021, DOI 10.1111/dth.15131. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | 7,7 %Voir la citationAdverse effects The reported complications were included hirsutism, weight gain, gastrointestinal intolerance, and hypotension, which have not been significantly different in the two treatment groups. (p=0.444). In group 1 (oral minoxidil), two cases (7.7%) of hirsutism, one case (3.8%) of overweight of 4 kg have been observed that were mild and tolerable, and they completed their treatments. Also, two cases (7.7%) with gastrointestinal intolerance and one case of hypotension (3.8%) were excluded from the study. In group 2 (2% topical minoxidil), two cases (8%) of hirsutism have been observed, which was not severe, and no one was excluded due to it (Table 3). Vahabi-Amlashi S, Layegh P, Kiafar B et al.. A randomized clinical trial on therapeutic effects of 0.25 mg oral minoxidil tablets on treatment of female pattern hair loss.. Dermatol Ther 2021, DOI 10.1111/dth.15131. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | Non testé |