Minoxidil topique 2 % face à Minoxidil topique 1 %

Table Nonvellus hair counts before and after 6 months oftreatment Nonvellus bair counts After I Treatmentgroup N Before 6rno Placebo 11 1140 1305 Minoxidil 0.01% 12 1258 1273 Minoxidil 0.1%* 10 1591 1850 Minoxidil 1%* 14 1305 1820 Minoxidil 2%* 11 1020 1615 Mean increase Mean diameter Totalincrease inhaircounts ofbaldspot in baircounts (SD) (em) 165 15 (20.33) 7.6 15 1.25 (51.86) 7.4 259 25.9 (41.18) 6.2 515 36.79 (33.26) 7.1 595 54.09 (31.69) 6.2 *Statisticallysignificantdifferencefromplaceboand0.01%minoxidilgroups(0.01 > p <0.001).

Shupack JL, Kassimir JJ, Thirumoorthy T et al.. Dose-response study of topical minoxidil in male pattern alopecia.. J Am Acad Dermatol 1987, DOI 10.1016/s0190-9622(87)70086-3. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table Nonvellus hair counts before and after 6 months oftreatment Nonvellus bair counts After I Treatmentgroup N Before 6rno Placebo 11 1140 1305 Minoxidil 0.01% 12 1258 1273 Minoxidil 0.1%* 10 1591 1850 Minoxidil 1%* 14 1305 1820 Minoxidil 2%* 11 1020 1615 Mean increase Mean diameter Totalincrease inhaircounts ofbaldspot in baircounts (SD) (em) 165 15 (20.33) 7.6 15 1.25 (51.86) 7.4 259 25.9 (41.18) 6.2 515 36.79 (33.26) 7.1 595 54.09 (31.69) 6.2 *Statisticallysignificantdifferencefromplaceboand0.01%minoxidilgroups(0.01 > p <0.001).

Shupack JL, Kassimir JJ, Thirumoorthy T et al.. Dose-response study of topical minoxidil in male pattern alopecia.. J Am Acad Dermatol 1987, DOI 10.1016/s0190-9622(87)70086-3. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table IV. Degree ofhair shedding: overall evaluation by the patients Treatmentgroup Decreased I Placebo 1 Minoxidil 0.01% 1 Minoxidil 0.1% 0 Minoxidil 1%* 7 Minoxidil 2%* 5 Evaluation Nochange I Increased N 10 0 11 11 0 12 10 0 10 7 0 14 6 0 11 *Statisticallysignificantdifferencefrom om%minoxidil andplacebogroups(p < 0.001).

Shupack JL, Kassimir JJ, Thirumoorthy T et al.. Dose-response study of topical minoxidil in male pattern alopecia.. J Am Acad Dermatol 1987, DOI 10.1016/s0190-9622(87)70086-3. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table IV. Degree ofhair shedding: overall evaluation by the patients Treatmentgroup Decreased I Placebo 1 Minoxidil 0.01% 1 Minoxidil 0.1% 0 Minoxidil 1%* 7 Minoxidil 2%* 5 Evaluation Nochange I Increased N 10 0 11 11 0 12 10 0 10 7 0 14 6 0 11 *Statisticallysignificantdifferencefrom om%minoxidil andplacebogroups(p < 0.001).

Shupack JL, Kassimir JJ, Thirumoorthy T et al.. Dose-response study of topical minoxidil in male pattern alopecia.. J Am Acad Dermatol 1987, DOI 10.1016/s0190-9622(87)70086-3. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Change from baseline target area hair Change from base- line target area hair Placebo 0.01% counts (N = 18) (N -- lS) Vellus (_SD) 9 (-+89) 37 (---59) Range - 154~. 195 -55, 164 Nonvellus (-+SD) 81 (---95) 48 (+57) Range -37,251 -52, 162 Total (__SD) 90 (___89) 84 (+-69) Range -40, 286 -21, 161 SD: Standard deviation.

Citation complémentaire (methode)

thus conservative. Univariate analyses were inspected for differences between dose levels with the use of Duncan's multiple range test at a significance level of 0.05. In addition, X2 tests were used to evaluate dif-

Citation complémentaire (significativite)

sis, the changes in (log) total and (log) nonvellus hair counts were significantly associated with treat- ment group (p = 0.04 and 0.02, respectively; Table III). The change from baseline vellus hair counts were not significantly associated with treat- ment group (p = 0.43). Duncan's multiple range test indicated that, for (log) total hair counts, the 2% minoxidil treatment group results were signif- icantly greater than the 0.01% and 0.1% topical minoxidil and placebo groups. The nonvellus (log) count was also significantly greater for the 2% topical minoxidil group than for the 0.01% topical minoxidil and placebo groups. There was no sta- tistically significant difference between the 2% and 1% topical minoxidil groups in terms of mean change in nonvellus or total hair counts from base- line to the end of this study.

Citation complémentaire (valeur)

counts relative to treatment group Treatment group Topical minoxidil 2% 0.1% I 1% (N = 15) (N = 15) (N = 17) 11 (±87) -31 (+_92) -15 (+_ 121) - 184, 123 -245, 58 -342, 176 81 (_+68) 180 (_+ 126) 190 (___ 136) -32, 267 27, 395 38, 551 92 (-+79) 149 (+93) 175 (+99) -30, 209 15,362 38, 347

Olsen EA, DeLong ER, Weiner MS. Dose-response study of topical minoxidil in male pattern baldness.. J Am Acad Dermatol 1986, DOI 10.1016/s0190-9622(86)70138-2. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Change from baseline target area hair Change from base- line target area hair Placebo 0.01% counts (N = 18) (N -- lS) Vellus (_SD) 9 (-+89) 37 (---59) Range - 154~. 195 -55, 164 Nonvellus (-+SD) 81 (---95) 48 (+57) Range -37,251 -52, 162 Total (__SD) 90 (___89) 84 (+-69) Range -40, 286 -21, 161 SD: Standard deviation.

Citation complémentaire (valeur)

counts relative to treatment group Treatment group Topical minoxidil 2% 0.1% I 1% (N = 15) (N = 15) (N = 17) 11 (±87) -31 (+_92) -15 (+_ 121) - 184, 123 -245, 58 -342, 176 81 (_+68) 180 (_+ 126) 190 (___ 136) -32, 267 27, 395 38, 551 92 (-+79) 149 (+93) 175 (+99) -30, 209 15,362 38, 347

Olsen EA, DeLong ER, Weiner MS. Dose-response study of topical minoxidil in male pattern baldness.. J Am Acad Dermatol 1986, DOI 10.1016/s0190-9622(86)70138-2. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Change from baseline target area hair Change from base- line target area hair Placebo 0.01% counts (N = 18) (N -- lS) Vellus (_SD) 9 (-+89) 37 (---59) Range - 154~. 195 -55, 164 Nonvellus (-+SD) 81 (---95) 48 (+57) Range -37,251 -52, 162 Total (__SD) 90 (___89) 84 (+-69) Range -40, 286 -21, 161 SD: Standard deviation.

Citation complémentaire (methode)

thus conservative. Univariate analyses were inspected for differences between dose levels with the use of Duncan's multiple range test at a significance level of 0.05. In addition, X2 tests were used to evaluate dif-

Citation complémentaire (significativite)

sis, the changes in (log) total and (log) nonvellus hair counts were significantly associated with treat- ment group (p = 0.04 and 0.02, respectively; Table III). The change from baseline vellus hair counts were not significantly associated with treat- ment group (p = 0.43). Duncan's multiple range test indicated that, for (log) total hair counts, the 2% minoxidil treatment group results were signif- icantly greater than the 0.01% and 0.1% topical minoxidil and placebo groups. The nonvellus (log) count was also significantly greater for the 2% topical minoxidil group than for the 0.01% topical minoxidil and placebo groups. There was no sta- tistically significant difference between the 2% and 1% topical minoxidil groups in terms of mean change in nonvellus or total hair counts from base- line to the end of this study.

Citation complémentaire (valeur)

counts relative to treatment group Treatment group Topical minoxidil 2% 0.1% I 1% (N = 15) (N = 15) (N = 17) 11 (±87) -31 (+_92) -15 (+_ 121) - 184, 123 -245, 58 -342, 176 81 (_+68) 180 (_+ 126) 190 (___ 136) -32, 267 27, 395 38, 551 92 (-+79) 149 (+93) 175 (+99) -30, 209 15,362 38, 347

Olsen EA, DeLong ER, Weiner MS. Dose-response study of topical minoxidil in male pattern baldness.. J Am Acad Dermatol 1986, DOI 10.1016/s0190-9622(86)70138-2. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Change from baseline target area hair Change from base- line target area hair Placebo 0.01% counts (N = 18) (N -- lS) Vellus (_SD) 9 (-+89) 37 (---59) Range - 154~. 195 -55, 164 Nonvellus (-+SD) 81 (---95) 48 (+57) Range -37,251 -52, 162 Total (__SD) 90 (___89) 84 (+-69) Range -40, 286 -21, 161 SD: Standard deviation.

Citation complémentaire (valeur)

counts relative to treatment group Treatment group Topical minoxidil 2% 0.1% I 1% (N = 15) (N = 15) (N = 17) 11 (±87) -31 (+_92) -15 (+_ 121) - 184, 123 -245, 58 -342, 176 81 (_+68) 180 (_+ 126) 190 (___ 136) -32, 267 27, 395 38, 551 92 (-+79) 149 (+93) 175 (+99) -30, 209 15,362 38, 347

Olsen EA, DeLong ER, Weiner MS. Dose-response study of topical minoxidil in male pattern baldness.. J Am Acad Dermatol 1986, DOI 10.1016/s0190-9622(86)70138-2. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).