Minoxidil topique 5 % face à Cétirizine topique 1 %
1 essai les comparent directement, sur les mêmes patients. Voir Minoxidil topique 5 % · Voir Cétirizine topique 1 %
Un seul petit essai de fiabilité limitée (Hossein Mostafa 2021, 40 hommes de 18 à 49 ans avec alopécie androgénétique) a opposé le minoxidil topique 5 % à la cétirizine topique 1 % pendant 16 semaines, sans tester les écarts. Le médecin juge améliorés 25 % des patients sous minoxidil contre 33 % sous cétirizine, mais les patients se disent plus souvent améliorés sous minoxidil (58 % contre 31 %), et 75 % sont stabilisés contre 50 %. Les résultats divergent selon le critère et restent à confirmer.
Hossein 2021
Essai randomisé, risque de biais élevé. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study
| Critère | Minoxidil topique 5 % | Cétirizine topique 1 % | Écart |
|---|---|---|---|
| Patients améliorés (évaluation investigateur) | 25 %Voir la citation(Figures 2A, 2B and 3). Based on physicians’ opinions, after 16 weeks of treatment in the cetirizine group, hair density in 33% of participants slightly increased, 50% of participants did not differ in hair 193 J Pharm Pharm Sci (www.cspsCanada.org) 24, 191 - 199, 2021 density and in 17% of the subjects hair density slightly decreased. Whereas in the minoxidil group, 25% had a slight increase in hair density and in 75% of participants no changes from baseline were detectable (Figure 2A). In the cetirizine group, after 8 weeks of using the placebo solution, by comparing weeks 16 and 24, hair density in 25% of participants slightly increased, 41% experienced no difference in their hair density Figure 1. Changes in Biometric Indices of Hair along 24 Weeks of Study in Both Groups Cetirizine, Minoxidil. A) Total hair density, B) vellus hair density, C) terminal hair density, D) Percentage of hair in anagen phase, E) Percentage of hair in telogen Hossein Mostafa D, Samadi A, Niknam S et al.. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study. Journal of Pharmacy and Pharmaceutical Sciences 2021. Citation sous licence CC-BY-SA. | 33 %Voir la citation(Figures 2A, 2B and 3). Based on physicians’ opinions, after 16 weeks of treatment in the cetirizine group, hair density in 33% of participants slightly increased, 50% of participants did not differ in hair 193 J Pharm Pharm Sci (www.cspsCanada.org) 24, 191 - 199, 2021 density and in 17% of the subjects hair density slightly decreased. Whereas in the minoxidil group, 25% had a slight increase in hair density and in 75% of participants no changes from baseline were detectable (Figure 2A). In the cetirizine group, after 8 weeks of using the placebo solution, by comparing weeks 16 and 24, hair density in 25% of participants slightly increased, 41% experienced no difference in their hair density Figure 1. Changes in Biometric Indices of Hair along 24 Weeks of Study in Both Groups Cetirizine, Minoxidil. A) Total hair density, B) vellus hair density, C) terminal hair density, D) Percentage of hair in anagen phase, E) Percentage of hair in telogen Hossein Mostafa D, Samadi A, Niknam S et al.. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study. Journal of Pharmacy and Pharmaceutical Sciences 2021. Citation sous licence CC-BY-SA. | Non testé |
| Patients se jugeant nettement améliorés | 58 %Voir la citationcondition of their own hair were perused at weeks 16 and 24 of the study (Figure 2 C and D). In the cetirizine group, after 16 weeks of treatment in comparison to baseline, 31% of participants reported more improvement in hair fullness, 16% reported improving hair fullness and 16% mentioned worsening hair loss. Whereas, 37% didn’t feel any changes in their hair condition. The participants in the minoxidil group expressed more satisfaction about hair growth; 58% of them reported more improvement in hair fullness, 17% reported improving hair fullness. Finally, 17% didn’t feel any changes in their hair condition and 8% declared worsening hair loss. After 8 weeks of using the placebo solution in Hossein Mostafa D, Samadi A, Niknam S et al.. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study. Journal of Pharmacy and Pharmaceutical Sciences 2021. Citation sous licence CC-BY-SA. | 31 %Voir la citationcondition of their own hair were perused at weeks 16 and 24 of the study (Figure 2 C and D). In the cetirizine group, after 16 weeks of treatment in comparison to baseline, 31% of participants reported more improvement in hair fullness, 16% reported improving hair fullness and 16% mentioned worsening hair loss. Whereas, 37% didn’t feel any changes in their hair condition. The participants in the minoxidil group expressed more satisfaction about hair growth; 58% of them reported more improvement in hair fullness, 17% reported improving hair fullness. Finally, 17% didn’t feel any changes in their hair condition and 8% declared worsening hair loss. After 8 weeks of using the placebo solution in Hossein Mostafa D, Samadi A, Niknam S et al.. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study. Journal of Pharmacy and Pharmaceutical Sciences 2021. Citation sous licence CC-BY-SA. | Non testé |
| Patients stabilisés, sans gain ni perte | 75 %Voir la citation(Figures 2A, 2B and 3). Based on physicians’ opinions, after 16 weeks of treatment in the cetirizine group, hair density in 33% of participants slightly increased, 50% of participants did not differ in hair 193 J Pharm Pharm Sci (www.cspsCanada.org) 24, 191 - 199, 2021 density and in 17% of the subjects hair density slightly decreased. Whereas in the minoxidil group, 25% had a slight increase in hair density and in 75% of participants no changes from baseline were detectable (Figure 2A). In the cetirizine group, after 8 weeks of using the placebo solution, by comparing weeks 16 and 24, hair density in 25% of participants slightly increased, 41% experienced no difference in their hair density Figure 1. Changes in Biometric Indices of Hair along 24 Weeks of Study in Both Groups Cetirizine, Minoxidil. A) Total hair density, B) vellus hair density, C) terminal hair density, D) Percentage of hair in anagen phase, E) Percentage of hair in telogen Hossein Mostafa D, Samadi A, Niknam S et al.. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study. Journal of Pharmacy and Pharmaceutical Sciences 2021. Citation sous licence CC-BY-SA. | 50 %Voir la citation(Figures 2A, 2B and 3). Based on physicians’ opinions, after 16 weeks of treatment in the cetirizine group, hair density in 33% of participants slightly increased, 50% of participants did not differ in hair 193 J Pharm Pharm Sci (www.cspsCanada.org) 24, 191 - 199, 2021 density and in 17% of the subjects hair density slightly decreased. Whereas in the minoxidil group, 25% had a slight increase in hair density and in 75% of participants no changes from baseline were detectable (Figure 2A). In the cetirizine group, after 8 weeks of using the placebo solution, by comparing weeks 16 and 24, hair density in 25% of participants slightly increased, 41% experienced no difference in their hair density Figure 1. Changes in Biometric Indices of Hair along 24 Weeks of Study in Both Groups Cetirizine, Minoxidil. A) Total hair density, B) vellus hair density, C) terminal hair density, D) Percentage of hair in anagen phase, E) Percentage of hair in telogen Hossein Mostafa D, Samadi A, Niknam S et al.. Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-blind Controlled Study. Journal of Pharmacy and Pharmaceutical Sciences 2021. Citation sous licence CC-BY-SA. | Non testé |