Minoxidil 5 % + trétinoïne 0,01 %, une application par jour
1 étude, 31 participants · Alopécie androgénétique · Hommes
Ajouter de la trétinoïne 0,01 % au minoxidil 5 % n'apporte pas de différence significative par rapport au minoxidil 5 % seul, dans le seul essai disponible, petit et de fiabilité moyenne, mené chez 31 hommes atteints d'alopécie androgénétique (Shin 2007). En 18 semaines, le nombre de cheveux passe de 124,2 à 142,4 par cm² et l'épaisseur de 36,2 à 38,1 µm sous l'association, des écarts avec le minoxidil seul qui peuvent être dus au hasard. Une irritation du cuir chevelu touche 5 hommes sur 15.
Piste explorée
Ce traitement n'a été mesuré que dans une seule étude par critère : il n'existe pas encore assez d'essais pour en tirer une conclusion. Les résultats ci-dessous sont des indices, à lire avec leurs limites.
Les résultats
Critères mesurés dans une seule étude : chaque ligne est un résultat isolé.
Efficacité
- Densité de cheveux hors duvet42,7 → 48,8 cheveux par cm² face à Minoxidil topique 5 %
Voir la citation
Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.
Citation complémentaire (methode)
The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5
Citation complémentaire (significativite)
Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).
Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Proportion de cheveux en phase de croissance0,554 → 0,521 ratio face à Minoxidil topique 5 %
Voir la citation
Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.
Citation complémentaire (methode)
The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5
Citation complémentaire (significativite)
Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).
Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
- Vitesse de pousse du cheveu336,6 → 331,1 µm/jour face à Minoxidil topique 5 %
Voir la citation
Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.
Citation complémentaire (methode)
The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5
Citation complémentaire (significativite)
Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).
Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).
Comparé directement à
Traitements testés contre celui-ci dans un même essai, sur les mêmes patients.
- Minoxidil topique 5 % 1 essai
Les études
- Shin 2007 · Essai randomisé, risque de biais modéré. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial