Minoxidil topique 5 % face à Minoxidil 5 % + trétinoïne 0,01 %, une application par jour

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

± 2.1 37.4 ± 1.8 <0.05

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Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

± 13.1 317.7 ± 13.8 NS

Citation complémentaire (inclusion)

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Table III. Biologic parameters of hair growth at baseline and after 18 weeks of treatment in the two treatment groups Parameter Baselinea After treatmenta p-Value Combined minoxidil and tretinoin once-daily group Total hair count (n/cm2) 124.2 Non-vellus hair count (n/cm2) 42.7 ± 8.5 142.4 ± 7.3 <0.05 ± 5.8 48.8 ± 5.6 <0.05 Anagen hair ratio 0.554 ± 0.020 0.521 ± 0.037 NS Linear hair growth rate (μm/d) 336.6 Mean hair diameter (μm) 36.2 Minoxidil twice-daily Total hair count (n/cm2) 124.0 Non-vellus hair count (n/cm2) 33.4 ± 10.6 331.1 ± 9.3 NS ± 1.3 38.1 ± 1.4 NS ± 7.5 139.9 ± 9.1 <0.05 ± 4.3 47.4 ± 5.3 <0.05 Anagen hair ratio 0.571 ± 0.025 0.557 ± 0.035 NS Linear hair growth rate (μm/d) 302.2 Mean hair diameter (μm) 34.8 a Values are mean ± standard error. NS = not significant.

Citation complémentaire (methode)

The total hair count and non-vellus hair count increased signifi- cantly after 18 weeks of treatment in both groups (p < 0.05). Mean hair diameter was also markedly increased in the control group (p < 0.05). In the test group the increase in mean hair diameter was of borderline significance (p = 0.064). Neither anagen hair ratio nor baseline Parameter Combined minoxidil and tretinoin once-daily groupa Minoxidil twice-daily groupa p-Value Total hair count (n/cm2) 124.2 ± 8.5

Citation complémentaire (significativite)

Treatment Efficacy between Groups No significant differences in percentage changes in biologic parameters of hair growth (total hair count, non-vellus hair count, anagen hair ratio, linear hair growth rate, and mean hair diameter) were observed between the two groups after 18 weeks of treat- ment. The p-values all exceeded 0.05 (table IV).

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Five patients in the test group (n = 15) and four patients in the control group (n = 14) complained of scalp itching or prickling. Among them, two patients in the control group had folliculitis on their scalps.

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Five patients in the test group (n = 15) and four patients in the control group (n = 14) complained of scalp itching or prickling. Among them, two patients in the control group had folliculitis on their scalps.

Shin HS, Won CH, Lee SH et al.. Efficacy of 5% Minoxidil versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss: A Randomized, Double-Blind, Comparative Clinical Trial. American Journal of Clinical Dermatology 2007. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).