Lumière de basse intensité (casques et séances)

TABLE5. Summaryoffolliscopefindingafter4monthsoftreatmentamongthethreegroups GroupA(Minoxidil) Hairdensity(/cm2) Range 150–220 Average(cid:3)SD 191.53(cid:3)18.23 P-value <0.001(cid:1) Hairshaftdiameter(mm) Range 0.042–0.077 Average(cid:3)SD 0.05(cid:3)0.016 P-value 0.099 (cid:1)P<0.05isstatisticallysignificant. GroupB(LLLT) GroupC(combined) 170–220 190–235 195.53(cid:3)14.71 207.2(cid:3)12.97 <0.001(cid:1) <0.001(cid:1)

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Folliscopehairdensity(/cm2) Range 120–175 Average(cid:3)SD 141.93(cid:3)19.43 Hairshaftdiameter(mm) Range 0.034–0.077 Average(cid:3)SD 0.048(cid:3)0.016 StatisticalMethods Data were statistically described in terms of mean(cid:3) standarddeviation((cid:3)SD),medianandrange,orfrequen- cies(numberofcases)andpercentageswhenappropriate. Comparison of numerical variables between the study GroupB(LLLT) GroupC(Combined) P-value 27–45 25–49 0.207 35.67(cid:3)7.17 35.2(cid:3)8.86 2,13.3% 1,6.7% 0.760 13,86.7% 14,93.3% 3–15 1–15 0.701 6.27(cid:3)3.45 5.13(cid:3)4.34 8,53.3% 6,40% 0.529 7,46.7% 9,60% 9,60% 8,53.3% 0.757 6,40% 7,46.7% 2,13.3% 3,20% 0.859 13,86.7% 12,80% 2,13.3% 3,20% 0.377 10,66.7% 7,46.7% 3,20% 5,33.3% 6–22 6–22 0.118 14.8(cid:3)4.72 17.67(cid:3)4.24 0.099–0.162 0.1–0.158 0.168 0.129(cid:3)0.019 0.128(cid:3)0.018 121–175 120–180 0.888 145.47(cid:3)20.37 144.2(cid:3)20.42

Esmat SM, Hegazy RA, Gawdat HI et al.. Low level light-minoxidil 5% combination versus either therapeutic modality alone in management of female patterned hair loss: A randomized controlled study.. Lasers Surg Med 2017, DOI 10.1002/lsm.22684. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

TABLE 3. HairDensityandMeanHairThicknessofLow-LevelLightTherapyGroup(Per-ProtocolSet) HairDensity/cm2 Patient MeanHairThickness,lm No. Baseline 24 Weeks Difference Baseline 24 Weeks Difference KU-2 136 141 5 KU-3 113 134 21 KU-9 116 129 13 KU-13 74 82 8 KU-16 81 131 50 KU-20 117 129 12 SU-3 110 124 14 SU-4 110 122 12 SU-6 115 120 5 SU-9 137 167 30 SU-10 124 136 12 SU-15 142 153 11 SU-16 141 153 12 SU-19 116 136 20 SU-20 126 159 33 Mean (cid:3) SD 117.2 (cid:3) 19.6 134.4 (cid:3) 20.2 17.2

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TABLE 4. SummaryofMeansofChangesinHair DensityandMeanHairThicknessofShamDevice andLow-LevelLightTherapy(LLLT)Group(Per ProtocolSet) MeanHair Group HairDensity/cm2 Thickness,lm Shamdevice, –2.1 (cid:3) 18.3 3.9 (cid:3) 7.3 mean (cid:3) SD LLLT, 17.2 (cid:3) 12.1 12.6 (cid:3) 9.4 (cid:3) mean SD p-value(t-test) .003 .01

Kim H, Choi JW, Kim JY et al.. Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, sham device-controlled multicenter trial.. Dermatol Surg 2013, DOI 10.1111/dsu.12200. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

TABLE 3. HairDensityandMeanHairThicknessofLow-LevelLightTherapyGroup(Per-ProtocolSet) HairDensity/cm2 Patient MeanHairThickness,lm No. Baseline 24 Weeks Difference Baseline 24 Weeks Difference KU-2 136 141 5 KU-3 113 134 21 KU-9 116 129 13 KU-13 74 82 8 KU-16 81 131 50 KU-20 117 129 12 SU-3 110 124 14 SU-4 110 122 12 SU-6 115 120 5 SU-9 137 167 30 SU-10 124 136 12 SU-15 142 153 11 SU-16 141 153 12 SU-19 116 136 20 SU-20 126 159 33 Mean (cid:3) SD 117.2 (cid:3) 19.6 134.4 (cid:3) 20.2 17.2

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TABLE 4. SummaryofMeansofChangesinHair DensityandMeanHairThicknessofShamDevice andLow-LevelLightTherapy(LLLT)Group(Per ProtocolSet) MeanHair Group HairDensity/cm2 Thickness,lm Shamdevice, –2.1 (cid:3) 18.3 3.9 (cid:3) 7.3 mean (cid:3) SD LLLT, 17.2 (cid:3) 12.1 12.6 (cid:3) 9.4 (cid:3) mean SD p-value(t-test) .003 .01

Citation complémentaire (valeur)

(cid:3) 12.1 56.2 (cid:3) 17.9 68.8 (cid:3) 13.2 12.6 (cid:3) 9.4

Kim H, Choi JW, Kim JY et al.. Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, sham device-controlled multicenter trial.. Dermatol Surg 2013, DOI 10.1111/dsu.12200. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Atweek24,thelaserdevicewassignificantlysuperiorto theshamdeviceforincreasinghairdensityandhairdiameter (p=0.002 and p=0.009, respectively). Laser device-treated subjects showed a significantly greater increase in hair density at weeks 16 and 24, as well as in hair diameter at week 24, compared with sham device-treated subjects (all p<0.05; Fig. 2). The mean change from baseline to week 24 in hair density was 10.21±3.25 hairs/cm2 in the laser group versus 3.95±1.32 hairs/cm2 in the sham group. The mean change from baseline to week 24 in hair diameter was 6.11±2.15 μm in the laser group versus 3.76 ±1.24μmintheshamgroup.

Suchonwanit P, Chalermroj N, Khunkhet S. Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial.. Lasers Med Sci 2019, DOI 10.1007/s10103-018-02699-9. Citation sous licence CC-BY.

The average hair shaft diameter for each patient, taken at 15 cm from the glabella, is depicted in Figure 8. Four out of seven patients had an increase in the width of their hairs, while three patients had a decrease. Paired t-testing indicates that at 3 months, patients had an average hair shaft diameter that was 1.0 μm wider than at baseline. However, this was not statistically signifi cant (p(cid:2) 0.5351).

Avram MR, Rogers NE. The use of low-level light for hair growth: part I.. J Cosmet Laser Ther 2009, DOI 10.1080/14764170902842531. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

The average shaft diameter, taken at 20 cm from the glabella, is depicted in Figure 9. Three out of seven patients had an increase in the width of their hairs, while four patients had a decrease. Paired t-testing indicates that at 3 months patients had an average hair shaft diameter that was 0.97 μm narrower than at baseline. Again, this was not statistically signifi cant (p(cid:2) 0.5161).

Avram MR, Rogers NE. The use of low-level light for hair growth: part I.. J Cosmet Laser Ther 2009, DOI 10.1080/14764170902842531. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Atweek24,thelaserdevicewassignificantlysuperiorto theshamdeviceforincreasinghairdensityandhairdiameter (p=0.002 and p=0.009, respectively). Laser device-treated subjects showed a significantly greater increase in hair density at weeks 16 and 24, as well as in hair diameter at week 24, compared with sham device-treated subjects (all p<0.05; Fig. 2). The mean change from baseline to week 24 in hair density was 10.21±3.25 hairs/cm2 in the laser group versus 3.95±1.32 hairs/cm2 in the sham group. The mean change from baseline to week 24 in hair diameter was 6.11±2.15 μm in the laser group versus 3.76 ±1.24μmintheshamgroup.

Suchonwanit P, Chalermroj N, Khunkhet S. Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial.. Lasers Med Sci 2019, DOI 10.1007/s10103-018-02699-9. Citation sous licence CC-BY.

TABLE6. Patientsatisfactionlevelamongthethreegroups Satisfaction GroupA(Minoxidil)(%) 0 3,20 1 6,40 2 5,33.3 3 1,6.7 GroupB(LLL)(%) GroupC(combined)(%) 3,20 0,0 7,46.7 2,13.3 4,26.7 6,40 1,6.7 7,46.7

Esmat SM, Hegazy RA, Gawdat HI et al.. Low level light-minoxidil 5% combination versus either therapeutic modality alone in management of female patterned hair loss: A randomized controlled study.. Lasers Surg Med 2017, DOI 10.1002/lsm.22684. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle).

Incidenceofadversereactionswasnotsignificantlydiffer- entbetweentwogroups.Therewasnoseriousadverseevent reportedinanysubject.Onefemalesubjectinthelasergroup complained of increased hair shedding, which occurred at 2 weeks after starting treatment and spontaneously resolved within6weeks.Mildscalpitchingwasdescribedintwolaser-

Suchonwanit P, Chalermroj N, Khunkhet S. Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial.. Lasers Med Sci 2019, DOI 10.1007/s10103-018-02699-9. Citation sous licence CC-BY.

Incidenceofadversereactionswasnotsignificantlydiffer- entbetweentwogroups.Therewasnoseriousadverseevent reportedinanysubject.Onefemalesubjectinthelasergroup complained of increased hair shedding, which occurred at 2 weeks after starting treatment and spontaneously resolved within6weeks.Mildscalpitchingwasdescribedintwolaser-

Suchonwanit P, Chalermroj N, Khunkhet S. Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial.. Lasers Med Sci 2019, DOI 10.1007/s10103-018-02699-9. Citation sous licence CC-BY.

within6weeks.Mildscalpitchingwasdescribedintwolaser- LasersMedSci(2019)34:1107–1114 Fig.3 Globalphotographic 14 assessmentbasedonpairedglobal photographsfrombaselineto 12 week24byinvestigators(a)and patients(b).Subjectstreatedwith stcejbus thelaserdeviceshoweda 10 significantlygreaterimprovement forbothevaluations(p=0.0002 8 andp=0.0026,respectively) fo rebmuN 6 4 2 0 1111 RAMACAP Sham device mild deteriora(cid:2)on no change mild moderate marked a 14 12 stcejbus 10 8 fo rebmuN 6 4 2 0 improvement improvement improvement Global photographic assessment by investigators RAMACAP Sham device mild deteriora(cid:2)on no change mild moderate marked b treatedsubjectsandonesham-treatedsubjectwithouttheneed for treatment. No subject experienced an adverse event that resultedinthediscontinuationorinterruptionofthestudy.

Suchonwanit P, Chalermroj N, Khunkhet S. Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial.. Lasers Med Sci 2019, DOI 10.1007/s10103-018-02699-9. Citation sous licence CC-BY.