Minoxidil topique 5 % face à Microneedling électrique, 8 séances toutes les 3 semaines
1 essai les comparent directement, sur les mêmes patients. Voir Minoxidil topique 5 % · Voir Microneedling électrique, 8 séances toutes les 3 semaines
Chez 75 hommes chinois atteints d'alopécie androgénétique, un seul essai de fiabilité limitée a opposé le minoxidil topique 5 % à 8 séances de microneedling électrique (Bao 2022). En 24 semaines, le gain de cheveux épais par cm² ne diffère pas significativement (+28,01 sous minoxidil contre +32,09 sous microneedling), mais le minoxidil épaissit nettement plus le cheveu (+18,7 µm contre +10,41 µm).
Bao 2022
Essai randomisé, risque de biais élevé. Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway.
| Critère | Minoxidil topique 5 % | Microneedling électrique, 8 séances toutes les 3 semaines | Écart |
|---|---|---|---|
| Gain de cheveux non-duvet depuis le départ | +28,01 cheveux par cm²Voir la citationTable 2. Changes in hair density after 24 weeks One-sample t test Hair count/cm2 Group 1 (n = Group 2 (n = Group 3 (n = 23) 23) 25) Non-vellus hair 28.01 ± 7.42 32.09 ± 4.51 56.45 ± 7.82 count P = 0.002 P = 0.004 P = 0.002 Vellus hair -13.74 ± 3.41 -10.56 ± 2.83 -16.67 ± 6.48 count P = 0.014 P = 0.064 P = 0.021 14.27 ± 3.24 21.53 ± 6.19 39.78 ± 7.79 Total hair count P = 0.046 P = 0.074 P < 0.001 of treatment P value One-way ANOVA Two-sample t test P value among the Group 1 vs Group 1 vs Group 2 vs three groups Group 2 Group 3 Group 3 t P < 0.001 P = 0.513 P < 0.001 P < 0.001 Bao L, Zong H, Fang S et al.. Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway.. J Dermatolog Treat 2022, DOI 10.1080/09546634.2020.1770162. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | +32,09 cheveux par cm²Voir la citationTable 2. Changes in hair density after 24 weeks One-sample t test Hair count/cm2 Group 1 (n = Group 2 (n = Group 3 (n = 23) 23) 25) Non-vellus hair 28.01 ± 7.42 32.09 ± 4.51 56.45 ± 7.82 count P = 0.002 P = 0.004 P = 0.002 Vellus hair -13.74 ± 3.41 -10.56 ± 2.83 -16.67 ± 6.48 count P = 0.014 P = 0.064 P = 0.021 14.27 ± 3.24 21.53 ± 6.19 39.78 ± 7.79 Total hair count P = 0.046 P = 0.074 P < 0.001 of treatment P value One-way ANOVA Two-sample t test P value among the Group 1 vs Group 1 vs Group 2 vs three groups Group 2 Group 3 Group 3 t P < 0.001 P = 0.513 P < 0.001 P < 0.001 Bao L, Zong H, Fang S et al.. Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway.. J Dermatolog Treat 2022, DOI 10.1080/09546634.2020.1770162. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | Peut être dû au hasard |
| Gain de diamètre depuis le départ | +18,7 µmVoir la citationTable 3. Mean change in hair thickness from baseline to week 24 One-sample t test Group 1 (n = Group 2 (n = Group 3 (n = 23) 23) 25) Change in 18.70 ± 6.17 10.41 ± 4.83 22.46 ± 3.87 Non-vellus hair P < 0.001 P = 0.058 P < 0.001 thickness (μm) Data are presented as the mean ± standard deviation. One-way P value ANOVA Two-sample t test P value among Group 1 vs Group 1 vs Group 2 vs the three groups Group 2 Group 3 Group 3 t P = 0.002 P = 0.015 P = 0.259 P < 0.001 Bao L, Zong H, Fang S et al.. Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway.. J Dermatolog Treat 2022, DOI 10.1080/09546634.2020.1770162. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | +10,41 µmVoir la citationTable 3. Mean change in hair thickness from baseline to week 24 One-sample t test Group 1 (n = Group 2 (n = Group 3 (n = 23) 23) 25) Change in 18.70 ± 6.17 10.41 ± 4.83 22.46 ± 3.87 Non-vellus hair P < 0.001 P = 0.058 P < 0.001 thickness (μm) Data are presented as the mean ± standard deviation. One-way P value ANOVA Two-sample t test P value among Group 1 vs Group 1 vs Group 2 vs the three groups Group 2 Group 3 Group 3 t P = 0.002 P = 0.015 P = 0.259 P < 0.001 Bao L, Zong H, Fang S et al.. Randomized trial of electrodynamic microneedling combined with 5% minoxidil topical solution for treating androgenetic alopecia in Chinese males and molecular mechanistic study of the involvement of the Wnt/β-catenin signaling pathway.. J Dermatolog Treat 2022, DOI 10.1080/09546634.2020.1770162. Citation reproduite au titre du droit de courte citation (article L122-5 du Code de la propriété intellectuelle). | Probablement réel |